Process - Canton Biologics

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Antibody Discovery Developability Assessment

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Cell Line Development High-Efficiency Expression Vector

Process Analytical Methods Microbial CGT

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Technology Platforms

Cell Line Platform

CHOzen® CHOFlow® GS-KO GlycoExpress® Other Commercial Cell Lines Canvector®

Process Development Platform

CHO-Rise® CBoost® CanPure™ Purification Platform CanCapture™ Membrane Chromatography Platform CanConcentra™ High-Concentration Formulation Platform

Manufacturing Platform

Scale-Plus Technology Biologics Pulsing Production Line

IgMaxTM

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类别产品类型领域

Process

Upstream Process Development

Focus on quality

・Quality by Design
・Risk Management

Competitive development time

・From cell pool to 15L process in 4 months;
・Upstream process lock from a Top 1 cell poolcan be achieved in as fast as 2.5 months;

Unique cell culture platforms

・Orbital shaken cell culture system (10-2500L);
・Stirred-tank Reactor (3L to 2000L);

Advanced upstream cellculture platforms

・Fed-batch culture;
・Intensive fed-batch culture;
・Perfusion culture.

Titer up to ~39 g/L.

Perfusion culture obtains higher
cell fineness and longer culture time.

CBoost™‌

High Inoculation Density and High Expression Levels

Based on optimized inoculation strategies, volumetric productivity is significantly enhanced.

Highly Platformized

Applicable to multiple cell lines and product types, facilitating process transfer and scale-up.

Robust Process with Broad Applicability

The process remains stable across differentscales and culture modes, supporting flexible manufacturing strategies.

CBoost Advanced

Fed-batch Perfusion Culture

High cell viability is maintained through precise nutrient feeding and metabolite control.

Extended Culture Duration

Long-term production is achieved at sustained high cell density, increasing yield per batch.

Maximize Production Efficiency

Comprehensive optimization of process parameters to fully leverage cellular expression potential.

Orbital Shaker Bioreactor Platform

Advantages

Shorter mixing time

Lower shear force

Fewer air bubbles

Easy scale-up

Issues in Stirred-TankReactor (STR) Culture

・Low Viability, Low Viable Cell Density
・Protein Aggregation, Low Expression Titer

Switch to OrbitalShaker Bioreactor

・Both cell growth and expression titerhave been improved

Our Core Competencies

End-to-End Bioprocess Development

Bioprocess development services ready for tech-transfer and scale-up topilot and GMP production

CHO-Rise® Medium development platform

Self developed formula, localized manufacture, significantly reduced costs

Flexible culture platform

Stirred bioreactor, orbital shaken bioreactor

Next-Generation

Upgraded Formula

30% Enhancement VS Competitors

Serum-Free

Chemically Defined

Perfectly Compatible with Canton's Self-Developed CHOZen® Cells and CANVector® Systems

Excellent Cell Growth and Viability Performance

Powered by Cantonbio CHO-Rise Plus® , CHO-K1 maintains robust growthand near-100 % viability throughout 14-day fed-batch, outperforming commercial alternatives

Cell Growth

High Expression Level, Covering Multiple Modalities

With Cantonbio CHO-RisePlus® medium, mAbs, bsAbs, recombinant and hard-to-express proteins all achieve high titers above industrybenchmarks and competitors.

CHO Rise® Medium demonstrates excellent expression levels across multiple modalities

Using Cantonbio CHO-Rise Plus medium for antibody production significantly increases fucosylation and reduces high-mannose compared with competitors (left), or, for fucose-removal projects, employs a specialty cell line to eliminate fucose and lower high-mannose (right).

Glycosylation Analysis

Cantonbio CHO-Rise Plus® delivers higher product purity and lower fragments/aggregates than competitor media.

Product Purity

Cantonbio CHO-Rise Plus® yields antibodies with more consistent charge heterogeneity than competitor media.

Charge Variants

Trust from Customers

"With Canton's media, our CHO titers readily exceed gram levels and production costs drop sharply."

Process Director XX Biotech

"Canton's media delivers fast, stable target-protein expression, accelerating our lab projects."

University of HongKong Lab

Product Features

Animal-derived component-free

Chemically defined

Does not contain L-Glutamine (L-Gln) or phenol red

Applicable to: High-efficiencyrecombinant protein expression of cell lines including CHO-K1,CHOZN, CHO-S, and CHO-DG44 under fed-batch and high-density fed-batch processes

Name	Catalog Number	Type	Specification
CHO-Rise @ BM01 (Basal Medium)	CB-MCBO1L-1L	Liquid	1L
CHO-Rise @ BM01 (Basal Medium)	CB-MCB01P-1kg	Powder	10L/50L
CHO-Rise R BM02 (Basal Medium)	CB-MCB02L-1L	Liquid	1L
CHO-Rise R BM02 (Basal Medium)	CB-MCB02P-1kg	Powder	10L/50L
CHO-Rise R FM01 (Main Feed)	CB-MCFO1L-0.5L	Liquid	0.5L
CHO-Rise R FM01 (Main Feed)	CB-MCF01P-1kg	Powder	5L/50L
CHO-Rise R FM02 (Main Feed)	CB-MCFO2L-0.5L	Liquid	0.5L
CHO-Rise R FM02 (Main Feed)	CB-MCF02P-1kg	Powder	5L/50L
CHO-Rise @ FS01 (Supplemental Feed)	CB-MCS01L-0.2L	Liquid	0.2L
CHO-Rise @ FS01 (Supplemental Feed)	CB-MCS01P-0.2kg	Powder	1L/10L